ethyl 4,5,6,7-tetrahydro-1H-indazole-3-carboxylate - Names and Identifiers
Name | ethyl 4,5,6,7-tetrahydro-1H-indazole-3-carboxylate
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Synonyms | AKOS PAO-0218 4,5,6,7-tetrahydro-1H-indazoL ethyl 4,5,6,7-tetrahydro-1H-indazole-3-carboxylate ETHYL 4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOXYLATE 4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 1H-Indazole-3-carboxylic acid, 4,5,6,7-tetrahydro-, ethyl es...
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CAS | 4492-02-8
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ethyl 4,5,6,7-tetrahydro-1H-indazole-3-carboxylate - Physico-chemical Properties
Molecular Formula | C10H14N2O2
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Molar Mass | 194.23 |
Density | 1?+-.0.06 g/cm3(Predicted) |
Melting Point | 88 °C(Solv: ligroine (8032-32-4)) |
Boling Point | 403.5±45.0 °C(Predicted) |
pKa | 12.36±0.20(Predicted) |
Storage Condition | 2-8°C |
ethyl 4,5,6,7-tetrahydro-1H-indazole-3-carboxylate - Introduction
Ethyl 4,5,6, is an organic compound whose molecular formula is C12H15NO2. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: ethyl 4,5,6, colorless to yellow liquid.
-Melting point: approximately -70°C to -65°C.
-Boiling point: about 280 ℃ to 285 ℃.
-Density: about 1.11 to 1.13g/cm³.
-Soluble in some organic solvents at room temperature, such as ethanol and dimethylformamide.
Use:
- ethyl 4,5,6, can be used as an intermediate in organic synthesis and for the synthesis of other organic compounds.
-It can also be used in the pharmaceutical field, for example, as a synthetic raw material for antiepileptic drugs.
Preparation Method:
The preparation of ethyl 4,5,6, is usually carried out by the following steps:
1. First, ethyl 2-aminobenzoate is condensed with chloroacetic acid to produce methyl 2-chloroacetate.
2. Then, 2-chloroacetic acid benzene methyl ester is condensed with benzoyl chloride by an oxylic reagent (such as red phosphorus or trimethyl sulfoxide) to generate 4,5, 6,7-tetrahydro-1H-indazole-3-carboxylic acid chloride.
3. Finally, 4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid chloride is reacted with ethanol to generate ethyl 4,5,6, Ni.
Safety Information:
- ethyl 4,5,6, specific toxicity and safety measures have not been reported in detail. However, since it is an organic compound, it should generally be used and handled under appropriate chemical laboratory conditions.
-Use following proper laboratory procedures and wearing protective equipment such as laboratory gloves and goggles.
-It should be stored in a closed container, away from fire sources and high heat, and avoid contact with oxidants and acids.
Last Update:2024-04-09 21:04:16